Glutathione Facts

glutathione oxidized solubility

Whey protein to fight cancer, improves immunity and other health benefits

Studies show whey protein supplement is even better than previously thought. Although the health benefits of whey protein have been recently specified the use of whey protein for medicinal purposes has been prescribed since the time of Hippocrates. In fact, there are two ancient proverbs from the Italian city of Florence that say, "If you want to live a healthy and active, small milk" and "If everyone were raised on whey, doctors bankruptcy. "

In previous editions, we reported the extensive research showing the many potential benefits for the health of whey protein concentrate. The majority of this research was conducted in the 1980s and early 1990s, and was very persuasive. Scientists have continued their research on whey proteins with even more impressive results. The following are some of the most current research, interesting and useful information on whey protein.

Whey and Cancer

Other Studies were performed on animals from carcinogenic chemicals to see what whey protein concentrate effect cancer prevention or treatment. Scientists fed rats various proteins and then subjected to the powerful carcinogen dimethylhydrazine.

As with previous research, rats whey protein concentrate fed the tumors less and a reduction in the combined area of the tumor (tumor mass index). The researchers found that whey protein offered "considerable protection to the machine," rather other proteins, including soy. 1

Even proteins most exciting in vivo research on cancer and whey concentrate whey inhibited the growth of cancer cells breast cancer at low concentrations (Baruchel S. and G. Vaiu, Cancer Research, 1996). Finally, and most importantly, a fairly recent clinical study with cancer patients showed tumor regression when a patient fed whey protein concentrate 30 grams per day. 2

Whey and Glutathione

This new research using whey protein concentrate led researchers to a surprising discovery regarding the relationship between cancerous cells, glutathione (GSH) and whey protein concentrate. It was found that whey protein concentrate selectively depletes cancer cells of glutathione, which makes them more susceptible to treatments against cancer as radiotherapy and chemotherapy.

It was found that cancer cells and normal cells respond differently to nutrients and drugs that affect glutathione status. The most interesting thing to note is the fact that the concentration of glutathione in tumor cells is higher that surrounding normal cells. This difference in status between the cells of normal and cancer cells glutathione is considered an important factor in the resistance of cancer cells to chemotherapy.

As the researchers said, "Tumor cell GSH concentration may be among determinants of the cytotoxicity [poisonous to cells] of many chemotherapeutic agents and radiation, and an increase in GSH concentration appears to be at least one of the mechanisms of acquired resistance to chemotherapy drugs. "

They add: "It well known that rapid GSH synthesis in tumor cells is associated with high rates of cell proliferation. Depletion of GSH in vivo tumor decreases the rate of proliferation cell and inhibits cancer growth. "

The problem is that it is difficult to reduce glutathione sufficiently in tumor cells without threaten healthy tissue and put the cancer patient in a worse state. What is needed is a compound that can selectively cancer cells of deplete glutathione, while increasing, or at least maintain levels of glutathione in healthy cells.

This is exactly what whey protein seems to do. In this new research has found that cancer cells subjected to serum proteins were depleted of their glutathione, and growth was inhibited, while normal cells have an increase of GSH and increased cellular growth.

These effects have not been observed with other proteins. Not surprisingly, the researchers concluded, "Selective depletion of tumor GSH may in fact cancer cells more vulnerable action of chemotherapy and eventually protect normal tissues against the harmful effects of chemotherapy. "The exact mechanism by which whey protein to achieve this objective is not fully understood, but it seems that interferes with the feedback mechanism and regulation normal glutathione in cancer cells.

It is known that Glutathione Production is negatively inhibited by its own synthesis. Given that levels of basic glutathione in cancer cells are higher than normal cells, it is probably easier to reach the level of feedback negative correlation between levels of inhibition of cancer cells than in normal cells glutathione "The levels of glutathione.

Serum and LDL

The positive health benefits of whey protein concentrate is not limited in its effects on immunity and cancer prevention and treatment. whey protein concentrate also proved to be a potent inhibitor of lipoprotein oxidation low density. Current research indicates that the conversion of LDL to oxidation of LDL is the trigger that leads to atherosclerosis … training plaque and lesions associated with atherosclerosis.

Therefore, any substance that prevents oxidation of LDL is considered as anti-atherogenic. Although the protein of animal origin have traditionally been regarded as pro-atherogenic, protein Whey not seem to be an exception to the rule. Whey Protein is composed of several minor and major fractions, such as beta-lactoglobulin, alpha-lactalbumin, albumin, immunoglobulins and lactoferrin. It was found that the minor component responsible for the ability of whey protein concentrate to prevent oxidation of LDL appears to be the fraction of the lactoferrin protein. 3

Lactoferrin in serum

When lactoferrin was removed from the protein, the ability of whey protein concentrate to prevent LDL oxidation was significantly reduced, as leading researchers to speculate, "Our results suggest that LF (lactoferrin) is the main factor responsible for the effect inhibitor of the whey protein (LDL) and can work together in synergy with other factors in the whey protein, for example, alpha-lactalbumin. "

Another study in rats examined the effects of whey protein concentrate and casein on cholesterol and risk factors heart disease. Though casein (another milk protein from commonly used in research) is known to raise cholesterol in humans and animals, whey protein has the opposite effect, leading researchers noted, "the high level of protein in the diet Food [300 grams per kilogram of feed], whey protein significantly reduced plasma cholesterol and hepatic rate triglycerides. "4

The anti-cholesterol whey protein concentrate in this study has also been associated with a reduction in LDL cholesterol. The most interesting is the fact that this effect on cholesterol was not observed when the animals were fed amino acid mixtures that simulated whey protein, it is clear that there are properties in the whey that have these effects beyond its amino acid profile.

Serum and bone growth

Finally, whey protein appears to play a direct role in bone growth. The researchers found that rats fed with a whey protein concentrate showed increased bone strength and protein such as bone collagen. This discovery led to investigations of whether whey protein directly stimulated osteoblast (cell bone) growth in vitro.

Whey protein has been found to stimulate dose-dependent synthesis of total protein, DNA content, and increased hydroxyproline content of bone cells. 5

Note that not all whey protein concentrates are created equal. Processing of serum proteins to remove the lactose and fats without losing its biological activity takes special care by the manufacturer. Protein must be processed at low temperature and under conditions of low acid content so as not to "denature" the protein. Maintaining status natural protein is essential for biological activity.

These findings, together with the previous decade A study on whey protein, should convince anyone that whey protein concentrate protein is really aging.

Higher levels of glutathione and whey

A decade and a half of conclusions about the benefits of whey protein are profound.

Previous studies listed below:

* Whey protein concentrate dramatically raises glutathione levels. Glutathione is an essential antioxidant soluble in water in the body that protects cells and serves as a primary detoxifier of harmful compounds such as peroxides, heavy metals, carcinogens and other toxins.

* Glutathione is also intimately tied to immunity and Reduced Glutathione levels have been associated with disease such as AIDS, atherosclerosis, Alzheimer's and Parkinson's disease, just name a few. In fact, glutathione levels appear to be a form of modulation of immunity. 6

* Whey Protein Concentrate was found to increase steadily this very important antioxidant immune stimulant, beyond any protein studied (soybean) to levels above normal in several animal studies. 7

A small pilot study with HIV positive men who have been fed whey protein concentrate showed a dramatic increase in glutathione levels of all study participants, with two of three men they reach their ideal weight. 8

In fact, there have been several U.S. and international patents granted for the treatment of AIDS and improving the immunity protein in serum.

* Whey protein improves immune function and fights infections. Animals fed serum protein concentrate consistently showed dramatic improvement in the humoral and cellular a variety of immune challenges, such as Salmonella, Streptococcus pneumoniae 9 and extreme cancer-causing chemicals. This effect on immunity has not been observed with other proteins.

* Whey protein concentrate fights cancer. The animals fed protein whey.

References

1. (McIntosh GH. And al. Journal of Nutrition, 1995)
2. (RS Kennedy, GP Konok, G. Bounous, S. Baruchel, TD Lee, of Cancer Research, 1995)
3. (M. Kajikawa et al. Biochem et Biophysica Acta 1994)
4. (X. Zhang and AC Beyne Brit. J. Nutri., 1993)
5. (Y. Takada, AOE S., Kumegawa M., Biochemical Research Communications, 1996)
6. (Rosanne K., Min Fu Tsan Fidelus Immunology and Cell, 1986)
7. (Clin G. Bounous and P. Gold. Invest. Med 1991)
8. (G. Bounous, S. Baruchel, J. Faiutz, P. Gold, Clin. Invest. Med 1992)
9. (Bounous G., P. Konshavn, P. Gold, Clin. Invest. Med 1988)

About the Author

Want to learn how to gain muscle mass, lose fat, and save years of wasted time and money? Start by going to http://www.BrinkZone.com Learn how to eat and exercise for long term weight loss: http://www.FatLossRevealed