Glutathione Reductase
Vitamin C (ascorbic acid) supplements and diabetes
Because insulin facilitates the transport of vitamin C in the cells, most of the Diabetics suffer from vitamin C. intracellular Therefore, without vitamin C supplements in large doses, vitamin C compared exists in many diabetes despite "adequate" amount of vitamin C. A diabetic simply need more vitamin C in high doses of vitamin C is absolutely essential to treat diabetes.
Failure to correct a chronic, latent deficit of intracellular vitamin C leads to a series of problems to diabetes, including increased capillary permeability, poor wound healing, high cholesterol, and a system weakened immune. In addition, diabetes is also associated with increased free radical damage. Vitamin C is the main modulator of the activity free radicals in diabetes, improves glycemic control, reduce the accumulation of sorbitol in cells and inhibits protein glycosylation. sorbitol accumulation and glycosylation of proteins (both described below) are linked to many complications of diabetes, particularly diseases eyes and nerves.
Vitamin C provides a significant cost benefit in the treatment of diabetes. Based on information currently available, it appears that the effective dose of vitamin C in diabetic patients is around 1000-3000 milligrams per day in divided doses.
Sorbitol and diabetes complications
Sorbitol is a byproduct of glucose metabolism in the cell formed with the help of a enzyme aldose reductase. In people without diabetes, after sorbitol can be metabolized form, with the help of another enzyme (polyol Dehydrogenase) and fructose. This allows conversion of fructose sorbitol is excreted by the cell if they increase concentrations. Unfortunately, patients hyperglycaemic routine (high levels of blood sugar), sorbitol accumulates and plays an important role in the development chronic complications of diabetes.
The best way to understand the mechanism by which sorbitol is implicated in the development complications of diabetes who are planning to participate in the formation of cataracts. Although the target has no blood vessels, is an active metabolic tissue that continuously growing life. Hyperglycemia after operations glucose to sorbitol pathway. Since the target membrane is virtually impermeable sorbitol and lack the enzyme polyol dehydrogenase, sorbitol accumulates in high concentrations. These high levels persisted even when glucose levels return to normal.
This accumulation creates an osmotic gradient resulting in water entering in cells to maintain osmotic balance. As water is sucked into the cell must release small molecules such as amino acids, inositol, glutathione, niacin, vitamin C, magnesium and potassium to maintain osmotic balance. Because it compounds function to protect the lens against damage, loss of their results in an increased susceptibility to injury. Consequently, the delicate protein fibers in the lens becomes opaque, and form a cataract.
Drugs to inhibit the accumulation of sorbitol are extremely toxic. In contrast, vitamin C has an excellent safety profile and significantly reduced levels of sorbitol. Vitamin C doses as low as 100 milligrams per day, but usually 1,000 milligrams, normalizes red blood cell sorbitol in diabetic type I within 30 days trials, double-blind, randomized.
About the Author
Georgiy Kharchenko American Weight Loss Group LLC: Personal Trainer, Ephedra Products, Stimerex With Ephedra, lipodrene with ephedra
